Browsing: Cancer

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Jonnie Irwin is taking on a major new project and has invited fans along to watch the process.

The TV star and father-of-three is a bit of a legend when it comes to property, having made his name on the likes of A Place In The Sun, The Renovation Game and Escape To The Country.

Jonnie, a father to three young kids, is currently going through a devastating terminal cancer diagnosis, saying last year that he could ‘have months to live,’ and has been offered love and support from fans ever since.

He keeps followers updated on his day-to-day life, from his health to his family to everything in between, via Instagram, and this week revealed he was tackling a major renovation.

Taking to the site, he shared a video of a crew working ont he front of a nondescript two-storey house, revealing it was taken on day one of renovating the front of the building.

Describing it as ‘not the prettiest of houses,’ Jonnie shared his vision of putting in differently-designed windows, ripping own the porch and moving the doorway to the centre of the house.

The TV star is taking on a major renovation project (Picture: Instagram / Jonnie Irwin)

He shared the progress so far as he admitted it was ‘early days’ yet (Picture: Instagram / Jonnie Irwin)

‘Doing so brings in a big room in the middle of the house. That makes it an entrance hall which is better to live in,’ the property expert explained.

He said it was ‘early days but pretty exciting.’

Alongside the video, Jonnie shared in the caption that he was ‘a couple of days late posting this but I promised to be honest with my posts about this renovation- warts n all.’

The TV star was praised by fans and followers for his ‘passion’ in taking on the massive project, with one saying his ‘ideas sound great…will look amazing.’

‘It’s going to be fabulous Jonnie, can’t wait to see the finished result,’ another said,’ while one declared: ‘Property is what you do best apart from being super dad of course.’

Fans praised him as having a fantastic eye for renovations as well as being a ‘super dad’ (Picture: Instagram / Jonnie Irwin)

Jonnie shares three young sons with wife Jessica (Picture: instagram.com/jonnieirwintv)

And one fan wrote kindly: ‘You are a superstar! Keep going, push on through, get your energy from our love, so many people around the world are sending you love and healing and prayers,’ one wrote.

The former A Place In The Sun presenter announced in November 2022 that he could have months to live after being diagnosed with terminal cancer, with the disease having spread from his lungs to his brain.

In sharing updates on his life both online and in interviews, Jonnie recently marked an emotional final milestone with one of the three young sons he shares with his wife Jessica Holmes, on the tot’s final day of nursery school

‘Last EVER ride to nursery with Rex. Suitably waved off by Rafa and his spade and Rex with his game face on!’ the doting dad shared on social media.

Jonnie shared a trio of photos from the moment to mark the occasion, which showed Rex on his little bike, kitted out in a cool Batman helmet and cycling gloves, with his dad behind him as they posed for a picture in the driveway.

Macmillan cancer support If you or someone you care about has been diagnosed with cancer, Macmillan can offer support and information.
You can contact their helpline on 0808 808 00 00 (7 days a week from 8am to 8pm), use their webchat service, or visit their site for more information.

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Different cancer types behave in different ways (Picture: Getty/Science Photo Libra)

Scientists have identified how a specific substance plays a key role in helping prostate cancer to spread and become harder to treat.

They hope the findings might offer new treatment options for aggressive prostate cancer.

A team at Nottingham Trent University found that ‘transglutaminase 2’ (TG2), which is abundant in many of the body’s cells, is responsible for driving a process which leads to the progression and spreading of the disease.

In the UK, prostate cancer is the most common cancer in men – with more than 52,000 diagnosed every year.

Early prostate cancer cells require the male hormone androgen to grow.

However they can become androgen-independent and therefore harder to treat with current therapies, as they advance.

Researchers suggest that until now it has not been clear how that process occurs.

‘This finding has opened a significant pathway for understanding other key mechanisms prostate cancer cells utilise to evade key regulatory pathways,’ Dr Adeola Atobatele, a scientist on the study.

The new study found that a mutant form of TG2 is overproduced in prostate cancer and remains trapped inside the nucleus of cells.

There it restricts the levels of androgen response – making cancer cells the more aggressive androgen-independent.

It also increases expression of the protein mucin-1, which is known to be responsible for the growth and spreading of cancer.

Mucin-1 forms a mucous barrier on cell surfaces which protects cancer cells, researchers found.

When researchers analysed biopsies of prostate cancer, they identified increased levels of TG2.

Based on the findings, the team proposes that controlling the activity of TG2 and mucin-1 may offer a new therapeutic option for aggressive prostate cancer.

Lead scientist Dr Elisabetta Verderio Edwards, from Nottingham Trent University’s School of Science and Technology, said: ‘We wanted to explore why some cancer cells become androgen-independent and as a result more aggressive and harder to treat.

‘Transglutaminase is a multifunctional protein in all tissues and is involved in multiple processes.

‘We have now deepened our understanding of its key role in aggressive disease in prostate cancer patients.

‘Understanding this pathway is incredibly important.

‘This process plays a key role in cancer’s ability to evade treatment and so warrants further investigation in terms of potential future treatment and therapy.’

The latest study, which also involved the Polyclinic Hospital University (University of Messina) in Italy, is published in the journal Cell Death and Disease.

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