The motorway has been shut for a number of hours since the horrific crash this morning(Picture: LNP

Two elderly people were killed and 12 others injured after a horror crash on a busy motorway.

Emergency services were called to the scene between Junction 4 (High Wycombe) and Junction 5 (Stokenchurch) on the M40 in Buckinghamshire at around 8.15am today.

Thames Valley Police said around eigh vehicles were involved in the crash and two people sustained serious injuries, while another 10 suffered minor injuries and were taken to hospital.

Police said a woman in her sixties and a man in his seventies, died at the scene.

Their next of kin have been informed and are being supported by specially trained officers, police said.

Both sides of the motorway were closed for more than three hours to allow an air ambulance to land.

The route remains closed southbound, though northbound re-opened at 11.30am.

The crash happened on the southbound carriageway between Junction 4 and 5 on the M40 (Picture: Peter Manning/LNP)

Emergency services were called to the scene and a number of people who were injured were taken to hospital (Picture: Peter Manning/LNP)

Officers are carrying out collision investigation work and then vehicle recovery and clean-up will take place, National Highways said.

Thames Valley Police said: ‘Officers attended a report of an RTC involving multiple vehicles at around 8.15am today. Sadly two people have died. Their next of kin has been informed.

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‘Two more people have been taken to hospital with serious injuries. A further 10 people sustained minor injuries, some of whom have been taken to hospital.

A National Highways spokesperson added: ‘The M40 in Buckinghamshire is closed southbound between J5 (Stokenchurch) and J4 (Handy Cross / High Wycombe), due to a serious collision involving multiple vehicles. The incident occurred shortly before 8.15am this morning.

‘Thames Valley Police, Fire, Ambulance Services and National Highways Traffic Officers attended with Thames Valley Air Ambulance landing on the northbound carriageway. The northbound carriageway was also closed, but reopened circa 11.30.

‘Due to the nature of the incident, Thames Valley Police are carrying out collision investigation work.

‘Once complete, vehicle recovery and carriageway clean-up work can begin. The closure is expected to be protracted and in place for a considerable time today.’

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Thames Valley Police said two people sustained serious injuries, while another 10 suffered minor injuries and were taken to hospital.